Tilmicosin is a semi-synthetic antibiotic of the macrolide group and is believed to affect protein synthesis. It has bacteriostatic action but at high concentrations it may be bactericidal. This antibacterial activity is predominantly against Gram-positive microorganism with activity against certain gram-negative ones and Mycoplasma of a bovine, porcine, ovine and avian origin. In particular, its activity has been demonstrated against the following microorganism: Chickens and turkeys: Mycoplasma gallisepticum and Mycoplasma synoviae Scientific evidence suggests that macrolides act synergistically with the host immune system. Macrolides appear to enhance phagocyte killing of bacteria. Tilmicosin has been shown to inhibit in vitro the replication of the Porcine Reproductive and Respiratory Syndrome virus in alveolar macrophages in a dose dependent fashion. Cross-resistance between tilmicosin and other macrolides and lincomycin has been observed.
Each one ml contains:…………………………….278.2 Tilmicosin phosphate (Equivalent to 250 mg Tilmicosin base)
Chickens (except hens producing eggs for human consumption), Turkeys
Chickens&Turkeys: For the treatment and prevention of respiratory disease in chicken flocks, associated with Mycoplasma gallisepticum and M. synoviae
Dosage & Route of administration:
Route of administration: orally via drinking water.Route of administration: :orally via drinking water
.For whole product:Chickens (except henas producing eggs for human consumption):0.6–0.8 ml Tilmotil / Litre of drinking water, for 3 days.Turkeys (except hens producing eggs for human consumption):0.4 – 1.08 ml Tilmotil / Litre for 3 days in drinking water.
• For the treatment of chronic respiratory disease:0.55-0.825 gm Taylor / litre per drinking water for 3-5 days.
• For the treatment of necrotic enteritis:0.44 gm Taylor / liter per day for 3days.
For oral use only. Medicated drinking water or milk replacer should be prepared fresh every 24 hours
Contra – Indication:
Not authorised for use in laying birds producing eggs for human consumption. Do not use within 14 days of onset of the laying
Chicken: No symptoms of overdose have been seen in chickens given drinking water containing levels of Tilmicosin 5 times the recommended dose for 5 days. Daily treatment with 75 mg/litre for 10 days resulted in a reduction in faecal consistency.
Chickens – 12 days Turkeys – 19 days
Stored at temperature not exceed 30 C˚.