Devacoxroyal water soluble powder containing combination of Sulfadimidine and Trimethoprim. Sulfadimidine: is a pyrimidine sulfonamide antimicrobial agent, sulfonamide being structural analogue of Para amino benzoic acid (PABA), competitively inhibit the incorporation of BAPA into dihydropteroic acid the precursor of folic acid. Sulfadimidine: is readily absorbed following oral administration and therapeutic plasma level is rapidly attained. Trimethoprim: is a diaminopyrimidine antimicrobial agent, which is rapidly absorbed from the gastrointestinal tract Trimethoprim acts by preventing the reduction of dihydrofolate to tetrahydrofolate which required by the bacteria for biosynthesis of purines, pyrimidine and some amino acid. Sulfadimidine and Trimethoprim have similar broad spectrum of activity affecting on gram positive bacteria such as staphylococci spp, streptococci spp. and gram negative bacteria such as E.coli, salmonella, shigella, Haemophilus spp. and Pasteurella spp. and protozoa such as coccidia.
Each one gram contains:Each one gram contains: Sulfadimidine sodium………………………….464 mg. (Eq. to Sulfadimidine base 430 mg). Trimethoprim…………………………………..86 mg.
Broiler chicken:Broiler chicken:• Devacoxroyal is used for treatment of coccidiosis in broiler chickens caused by Eimeria tenella and Eimeria necatrix when administered in drinking water.• The combination is effective against enteric infection in broiler chicken caused by salmonella spp.• Infectious coryza caused by Haemophilus gallinarum. • Fowl cholera caused by Pasteurella spp.
Dosage & Route of administration:
Route of administration: orally via drinking water. For whole product: Broiler Chickens: 2.9 – 5.8 gm Devacoxroyal / 12 liters of drinking water for 3-5 days.
Medicated water should be replaced daily.
Contra – Indication:
Not used in laying birds where eggs or eggs product are to be used for human consumption.
Not reported in the recommended dose. Poultry: Prolonged treatment with Sulfonamides may cause petechial hemorrhages in poultry as a result of vitamin K antagonism causing agranulocytosis and hemolytic anemia.
Broiler chickens: not less than 14 days before slaughter.
Stored at temperature not exceed 30 C˚.