Royalmethox is an oral solution containing Sulphadimethoxine and Trimethoprim. Sulphadimethoxine has a low dose, rapidly absorbed long acting Sulfonamide, which produce its bacteriostatic effect by inhibiting the biosynthesis of folic acid by being mistakenly substituted for BAPA (Para-amino benzoic acid). Sulphadimethoxine has a broad spectrum of activity affecting on gram positive bacteria such as Staphylococci and gram negative bacteria such as E.coli, Haemophilus spp. Pasteurella spp. and Salmonella and protozoa such as coccidia. Trimethoprim: is a diaminopyrimidines antimicrobial agent, which act by preventing the reduction of dihydrofolate to tetrahydrofolate which required by the bacteria for biosynthesis of purines, pyrimidine and some amino acid. Because of their sequential action, Trimethoprim and sulfonamides potentiate each other, greatly increasing their individual antibacterial effects. The action of this combination is bactericidal, whereas the components used separately are generally bacteriostatic. Potentiating is shown even against bacteria that are generally resistant to one or other of the components.
Each one ml contains: Sulphadimethoxine sodium………………………. 199.9 mg. (Eq. to Sulphadimethoxine: 186.7 mg). Trimethoprim…………………………………………. 40 mg.
Treatment of respiratory diseases such as:
Treatment of respiratory diseases such as: Infectious coryza caused by Haemophilus paragallinarum.
Fowl cholera caused by Pasteurella multocida.
Treatment of Colibacillosis caused by E.coli.
Treatment of coccidiosis caused by Eimeria maxima, E.Tenella, E.acervulina, E.necatrix and E.brunetti.
Dosage & Route of administration:
Route of administration: Orally via drinking water. For whole product: 1-2 ml Royalmethox / litre of drinking water per day, for 5 days.
Medicated water should be replaced daily.
Contra – Indication:
Don’t use in case of allergic reaction to Sulfonamide or Trimethoprim. Don’t use in animal with hepatic or renal insufficiency.
Not reported in the recommended dose. Broiler chickens: Prolonged treatment with Sulfonamides may cause petechial hemorrhages in broiler chicken as a result of vitamin K antagonism causing agranulocytosis and hemolytic anemia.
Broiler chicken: 6 days.
Stored at temperature not exceed 30 C˚.