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Danofloxacin is a synthetic fluoroquinolone antimicrobial agent that possesses potent in vitro activity against Mannheimia haemolytica, Pasteurella multocida,  Histophilus somni and Escherichia coli, the bacterial pathogens most commonly associated with bovine respiratory, enteric disease and acute bovine mastitis.  

The antimicrobial activity of Danofloxacin is based upon the inhibition of microbial DNA gyrase and topoisomerase IV  The bactericidal effect is also observed on bacteria in the stationary growth phase


Each one ml contains: Danofloxacin 180 mg

Eq. to: Danofloxacin mesylate 228.4 mg

Target species:



In cattle: 

Treatment of bovine respiratory disease caused by Mannheimia haemolytica, Pasteurella multocida and Histophilus somni sensitive to Danofloxacin.

For the treatment of acute bovine mastitis caused by Escherichia coli sensitive to Danofloxacin.

In neo-natal calves:

Treatment of enteric infections caused by Escherichia coli sensitive to Danofloxacin.

Dosage & Route of administration:

Route of administration: Injection by the subcutaneous or intravenous route.

For whole product:


1 ml Danopharma / 30 kg body weight, as a single injection by the subcutaneous or intravenous route.

If clinical signs of respiratory or enteric disease persist 48 hours after the first injection, an additional dose at 1 ml/30 kg body weight may be administered.

Warning& Precaution:
  1. It is recommended to treat animals in the early stages of disease and to evaluate the response to treatment within 48 hours.
  2. For treatment of cattle weighing more than 450 kg, divide the subcutaneous dose so that no more than 15 ml are injected at one site.
  3. If clinical signs of acute bovine mastitis persist 36-48 hours after the first injection, the antibiotic treatment strategy should be reviewed.
Contra – Indication:

Do not be used in cases of known hypersensitivity to the active ingredient, to other (fluoro)quinolones or to any ingredients of the product.

Side Effects:

Subcutaneous injection of the product induces a moderate inflammatory response in the tissue around the injection site.  The resultant lesions may persist for up to 30 days.

Withdrawal time:

Meat and offal:  8 days

Milk:  4 days


Stored at temperature not exceed 30 C˚.